If you look at where most of the mutations are, they are similar to regions of the spike protein that have been seen with other variants so far and that tells you that despite mutations existing in other variants, the vaccines have continued to prevent very severe disease as we’ve moved through Alpha, Beta, Gamma and Delta.
At least from a speculative point of view we have some optimism that the vaccine should still work against this variant for severe disease but really we need to wait several weeks to have that confirmed.
But it is extremely unlikely that a reboot of a pandemic in a vaccinated population like we saw last year is going to happen